解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We have previously shown that AEV infection of leukosis-free chickens provokes an erythroleukemia in the infected birds, and that the target cell for virus transformation is most likely an early pro-erythroblast comparable to the BFU-E. The virus infection correlates with a block in differentiation which was studied a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290511
更新日期:1982-05-15 00:00:00
abstract::Turkey poults were inoculated with lymphoproliferative disease virus (LPDV) of turkey, and the organotropism of the inoculated virus was determined from the kinetics of virus expression and tumor formation. Molecular hybridization experiments, conducted to determine the level of viral RNA expression in the various org...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290518
更新日期:1982-05-15 00:00:00
abstract::From C57BL mouse melanoma B-16 cells, variant clones were selected in vitro which were resistant to the lectins wheat-germ agglutinin and ricin. Cells were also selected which survived toxic concentrations of concanavalin A. Four different in vivo assays using intradermal, intravenous, intraperitoneal and intramuscula...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290411
更新日期:1982-04-15 00:00:00
abstract::To test whether alloimmunization with H-2 or/and non-H-2 different normal tissues may increase the immunity to syngeneic tumors, groups of BALB/c (H-2d) mice were immunized with a series of allogeneic lymphoid cells and then challenged i.p. with syngeneic lymphoma cells. The outgrowth of otherwise lethal doses of the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290316
更新日期:1982-03-15 00:00:00
abstract::The antigen-induced leukocyte adherence inhibition (LAI) test is an assay of cellular immune reactivity which was expected to offer a promising adjunct to currently available diagnostic and monitoring procedures in cancer patients. We have applied this assay to (1) 83 inpatients clinically suspected of having breast c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290306
更新日期:1982-03-15 00:00:00
abstract::The purpose of this study was to induce in postnatal life the selective growth of altered hepatocytic populations which had been induced in utero by various chemicals. Pregnant rats of a Wistar strain were given a single dose of various chemical carcinogens on the 18th gestational day. From two months postpartum, both...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290317
更新日期:1982-03-15 00:00:00
abstract::The kinetics of the immune response of hamsters transplanted with virus-free SV40 tumor cells (TSV5) to two SV40-coded non-structural proteins of 94,000 daltons (T antigen) and 17,000 daltons (t antigen) was studied in order to determine if the variation in the immune reactivity of serum from tumor-bearing animals tow...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290218
更新日期:1982-02-15 00:00:00
abstract::A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TP...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290106
更新日期:1982-01-15 00:00:00
abstract::In combination with xenogeneic immune RNA (l-RNA) and tumor antigen (TA), syngeneic spleen cells inhibited the growth of a N-methyl-N-nitrosourethane-induced colon carcinoma (CT-26) in BALB/c mice. The sequential administration of 1 X 10(7) spleen cells, l mg of anti-CT-26 l-RNA and 0.4 mg of CT-26 TA resulted in a 20...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:1982-01-15 00:00:00
abstract::We compared and contrasted intracranial (i.c.) and subcutaneous (s.c.) heterotransplantation of small-cell carcinoma of the lung (SCCL) into athymic nude mice. Fresh human SCCL tumor specimens, tumor colonies grown in soft agarose and continuous cell lines were used. Tumors induced by the three types of specimens were...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280617
更新日期:1981-12-01 00:00:00
abstract::Female residents of six counties in Washington and Utah in whom a diagnosis of ovarian cancer was made during 1975-79 were interviewed concerning prior use of oral contraceptives. Interviews with a random sample of women drawn from these same counties were obtained for comparison. A smaller proportion of women with ep...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280602
更新日期:1981-12-01 00:00:00
abstract::Adherent cells with the ability to inhibit NK activity were found in the spleens of young 8-week-old SJL/J mice. Such suppressor cells were also found in the spleens of other low-NK-reactive strains, but not in the spleen of age-matched high-NK-reactive strains. These suppressor cells had the characteristics of macrop...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280621
更新日期:1981-12-01 00:00:00
abstract::Previously, the induction of pancreatic carcinogenesis in the rat using azaserine has involved a multiple-dose treatment protocol. The objective of the present study was to determine the effect of multiple azaserine treatments on pancreatic DNA synthesis and to develop a protocol for a single-dose initiation of pancre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280511
更新日期:1981-11-15 00:00:00
abstract::Human oocytes in different stages of maturation were obtained by follicular aspiration from women given Clomovid and Gonadex. Particles similar to type-C virus were observed in three out of 16 oocytes. The particles were irregularly distributed along the oocyte membrane. They were seen both in a state of budding and l...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280504
更新日期:1981-11-15 00:00:00
abstract::We obtained Thy-I-positive cells directly from growing methylcholanthrene-induced (MCA-1510) sarcomas using fluorescence-activated cell sorting, then cultured these lymphocytes in medium containing Interleukin-2 and tested their activity in vivo against various MCA-sarcoma lines with the Winn assay. We found that cult...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280513
更新日期:1981-11-15 00:00:00
abstract::Fischer rat thyroid epithelial cella (FRT) growing continuously in culture were infected with the Kirsten murine sarcoma virus KiMSV(KiMuLV) and found to produce this virus constitutively. Although the morphology of the FRT cells did not change appreciably, the cells became malignant after infection with KiMSV(KiMuLV)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280519
更新日期:1981-11-15 00:00:00
abstract::Lymphoma EL-4 of B6 origin was inoculated into lethally-irradiated syngeneic B6 or resistant BD2F1 hybrid recipients. Marked impairment of lymphoma cell proliferation (i.e. hybrid resistance, HR) occurred in the spleen but not in the liver or lung of BD2F1 hosts. Treatment with DTIC at the optimal dose of 80 mg/kg i.p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280416
更新日期:1981-10-15 00:00:00
abstract::The sister chromatid exchange (SCE) rates of cell lines derived from patients with different malignant and premalignant disease were studied before and after intracerebral inoculation into nude mice and were compared to the SCE frequencies of cell lines from healthy controls. Lymphoma lines characterized by chromosoma...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280408
更新日期:1981-10-15 00:00:00
abstract::EBV-specific cytotoxic T cells (Tc) induced in vitro have continuously proliferated in vitro for over 9 months. The long-term maintenance of the Tc growth was dependent on periodic supplementation of both irrediated EBV-transformed autologous lymphoblastoid cell line (LCL) cels and conditioned medium. The latter was d...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280205
更新日期:1981-08-15 00:00:00
abstract::Mouse and human lymphoid cells were cultivated in the presence of T-cell growth factor (TCGF) and evaluated for their in vivo anti-tumor effect in mice. Cultured spleen cells of normal BALB/c mice or of mice bearing the M109 tumor had a high level of cytotoxic activity in vitro against a variety of tumor target cells ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280208
更新日期:1981-08-15 00:00:00
abstract::Following exposure to feline leukemia virus (FeLV), cats that resist leukemia produce complement dependent antibodies (CDA) which lyse leukemia cells in the presence of cat complement. The CDA activity has been shown to be directed to feline oncornavirus-associated cell membrane antigen (FOCMA) found on the surface of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280215
更新日期:1981-08-15 00:00:00
abstract::The presence, concentration and selected molecular characteristics of the human mammary carcinoma glycoprotein molecule set MTGP, a trace and apparently tumor-specific molecule, were examined in fifteen cell cultures established from mammary carcinomas, tissue from seven mammary carcinomas and control cultures. Both c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280107
更新日期:1981-07-15 00:00:00
abstract::The relative proportions of T, B and T gamma suppressor cells were determined sequentially in peripheral blood of melanoma patients before and after surgery. Concanavalin A (Con A)-induced suppression against lymphocyte mitogenesis of melanoma patients and age matched controls was measured concurrently. The mean perce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280103
更新日期:1981-07-15 00:00:00
abstract::Tumorigenic clonal lines derived from soft agar colonies induced by DMBA-transformed feline embryo cells were isolated and characterized. The morphologically altered clonal cells formed large aggregates, growing in this aggregate form when suspended in liquid growth medium above an agar base and forming colonies in so...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280110
更新日期:1981-07-15 00:00:00
abstract::The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270616
更新日期:1981-06-15 00:00:00
abstract::A case of epidermodysplasia verruciformis in a patient from Upper-Volta is described. Slightly elevated, flat warts were observed on hands, feet, arms and legs, and pityriasis versicolor-like lesions were found mainly on the trunk. The patient showed no malignant tumors. Histological examination revealed hyperkeratosi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270511
更新日期:1981-05-15 00:00:00
abstract::Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with canine transmissible venereal sarcoma (CTVS) at different stages of growth was determined by the tube LAI test. Tumors were classified at the time of excision into progressor, steady state, and regressor stages of growth. The LAI ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270314
更新日期:1981-03-15 00:00:00
abstract::Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270310
更新日期:1981-03-15 00:00:00
abstract::The age-adjusted lung cancer incidence rates among Japanese, Chinese and Hawaiian women in Hawaii do not correlate to their respective cigarette smoking exposures. We conducted a case-control study to determine the lung cancer risk associated with smoking among these three ethnic groups of women by reviewing the medic...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270307
更新日期:1981-03-15 00:00:00
abstract::The activity of systemic and in situ natural killer (NK) cells was measured in 3- to 5-week-old CBA mice with progressively growing murine sarcoma virus (MSV)-induced tumors. Splenic NK activity was depressed in tumor-bearing mice. NK activity was quite low or not detectable in unfractionated cell suspensions from the...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270218
更新日期:1981-02-15 00:00:00
abstract::We have used immunoprecipitation to test tumor biopsies and normal adult and fetal human tissues for p97, a tumor-associated protein. Five of nine melanoma biopsies contained p97 in low to very high levels. Three of seven non-melanoma tumors contained p97, but in smaller amounts. No p97 was detected in any of the norm...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270204
更新日期:1981-02-15 00:00:00
abstract::Syrian-hamster-derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen-induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinog...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270108
更新日期:1981-01-15 00:00:00
abstract::G-banding analyses of 14 independently derived B-cell lymphomas showed the frequent occurrence of chromosome 15 trisomy. It was present in seven of nine spontaneous B-cell lymphomas, but in company with other trisomies, monosomies and marker chromosomes. In five carcinogen-induced primary B-cell leukemias, trisomy 15 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270109
更新日期:1981-01-15 00:00:00
abstract::The effects of single-agent therapy with two clinically useful drugs, 5-fluorouracil (5-FU) and 1-3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) against nine human colorectal tumors (rectum T 157 and T 348, lung metastasis T 84, lymph-node metastasis T 245, colon, T 183, T 219, T 347, T 362 and T 380) transplanted and pas...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270103
更新日期:1981-01-15 00:00:00
abstract::Fibronectin in human solid tumors was studied by indirect immunofluorescence staining of biopsy material. Altogether 73 tumors were examined, comprising 12 sarcomas, 3 melanomas 1 reticulum cell sarcoma, 39 carcinomas, 6 benign soft-tissue tumors and 12 benign epithelial tumors. In all sarcomas the individual tumor ce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270403
更新日期:1981-01-01 00:00:00
abstract::Single-cell suspensions prepared from five human melanomas, grown serially as xenografts in athymic nude mice, were exposed in vitro to increasing concentrations of DTIC (Dacarbazine), CCNU (Lomustine), procarbazine, vinblastine, and the cancerostatic lectins abrin and ricin. The in vitro chemosensitivity of the cells...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260604
更新日期:1980-12-15 00:00:00
abstract::Of 6- and 3-week-old nude mice given intravenous injections of murine tumor cells with well-defined metastatic properties, only the 3-week-old mice developed lung tumor colonies in significant numbers. The quantitative differences in metastatic potential among tumor cell lines injected into syngeneic recipients were a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260521
更新日期:1980-11-15 00:00:00
abstract::Two metastatic cell lines, mouse B16-Fl melanoma and human Hs939 melanoma, were examined for their abilities to adhere to confluent vascular endothelial cell monolayers and to the underlying endothelial extracellular matrix. Tumor cells attacked slowly to the endothelial cell monolayers while they adhered rapidly to i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260516
更新日期:1980-11-15 00:00:00
abstract::We have separated subpopulations of macrophages from an immunogenic fibrosarcoma by the technique of unit gravity velocity sedimentation. The activation state of these subpopulations was determined by measurement of the Fc receptor avidity of adherent cells, and by their 5' nucleotidase and acid phosphatase activity. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260513
更新日期:1980-11-15 00:00:00
abstract::Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4-h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260405
更新日期:1980-10-15 00:00:00